| 缪煜清,何清,欧阳瑞镯.铜基纳米材料在肿瘤领域的研究进展[J].有色金属材料与工程,2025,46(3):26-34. |
| 铜基纳米材料在肿瘤领域的研究进展 |
| Research progress of copper-based nanomaterials in the field of tumor |
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| DOI：10.13258/j.cnki.nmme.20240331001 |
| 中文关键词: 铜基纳米材料 细胞凋亡 肿瘤诊断 肿瘤成像 |
| 英文关键词:copper-based nanomaterials cell apoptosis tumor diagnosis tumor imaging |
| 基金项目:中国五矿集团有限公司科技专项计划资助项目（2022ZXA02） |
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| 中文摘要: |
| 恶性肿瘤已成为威胁人类健康的一类重要疾病，但传统治疗手段存在严重副作用且用传统手段治疗后该疾病复发率高。铜基纳米材料因其固有的理化性质、独特的生物学特性以及在生物体内具有关键作用，近年来被广泛研究。纳米技术的兴起极大地推动了铜基纳米材料的发展，尤其是在肿瘤领域的发展，促进了肿瘤成像和治疗的快速进步。讨论了铜基纳米材料的特性和在肿瘤治疗领域的潜在应用，涵盖铜在细胞内的代谢、铜稳态的重要性、肿瘤成像、肿瘤治疗，以及铜死亡与其他诱导细胞死亡方式的不同点。同时探讨了铜基纳米材料的生物相容性、当前研究重点以及未来在肿瘤治疗领域的应用前景。 |
| 英文摘要: |
| Malignant tumors have become an important category of diseases threatening human health, yet conventional therapies have serious side effects and a high recurrence rate of the disease after treatment with traditional methods. Copper-based nanomaterials have been widely studied in recent years due to their inherent physicochemical properties, unique biological characteristics and crucial roles in living organisms. The rise of nanotechnology has greatly promoted the development of copper-based nanomaterials, especially in the field of tumor, facilitating the rapid progress of tumor imaging and therapy. The characteristics of copper-based nanomaterials and their potential applications in the field of tumor treatment were discussed, including the intracellular metabolism of copper, the importance of copper homeostasis, tumor imaging, tumor therapy, and the differences between cuproptosis and other ways of inducing apoptosis. Meanwhile, the biocompatibility, current research focus and future application prospect of copper-based nanomaterials in the field of tumor therapy were also explored. |
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