| 车贤东,马凤仓,李伟,陈小红,刘新宽,张柯.TiO2-HA(掺杂Zn2+)复合涂层的制备及其生物学性能研究[J].有色金属材料与工程,2025,46(2):35-42. |
| TiO2-HA(掺杂Zn2+)复合涂层的制备及其生物学性能研究 |
| Preparation and biological performance study of TiO2-HA (doped with Zn2+) composite coating |
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| DOI：10.13258/j.cnki.nmme.20240312006 |
| 中文关键词: 复合涂层 表面改性 抗腐蚀性 抑菌性能 |
| 英文关键词:composite coating surface modification corrosion resistance antimicrobial properties |
| 基金项目:国家自然科学基金资助项目（51771119）；上海市自然科学基金资助项目（17ZR1419600） |
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| 中文摘要: |
| 羟基磷灰石（hydroxyapatite，HA）涂层具有良好的生物相容性和生物活性，已被广泛用作金属植入物的表面涂层。然而，HA涂层与钛合金基体的结合强度较低，植入后HA涂层容易剥落，致使其耐腐蚀性能下降，且其抑菌性能也有待提高。为了提高HA涂层的结合强度、耐腐性能及抑菌性能，对Ti6Al4V表面分别进行酸蚀处理、碱热处理、酸蚀后碱热处理，随后采用溶胶-凝胶法制备掺杂TiO2-HA（掺杂Zn2+）复合涂层。结果表明：通过溶胶-凝胶法成功合成了TiO2-HA（掺杂Zn2+）复合材料；Ti6Al4V经过碱热处理后HA涂层裂纹减少，提高了表面润湿性和耐腐蚀性能；TiO2和Zn2+的加入提高了HA涂层的完整性，提高了HA涂层耐腐蚀性能和润湿性，该涂层对金黄色葡萄球菌和大肠杆菌的抑菌率分别达到69.3%和96.9%，提高了抑菌性能。 |
| 英文摘要: |
| Hydroxyapatite (HA) coating has been widely used as the surface coating for metal implants due to its good biocompatibility and bioactivity. However, the HA coating has a low bond strength to the titanium alloy matrix and the HA coating tends to flake off after implantation, leading to a decrease in corrosion resistance, and its antibacterial properties need to be improved. To enhance the bond strength, corrosion resistance, and antimicrobial properties of the HA coating, the surface of Ti6Al4V was respectively subjected to acid etching, alkali heat treatment, and alkali heat treatment after acid etching. Subsequently, TiO2-HA (doped with Zn2+) composite coatings were prepared using the sol-gel method. The results indicate that TiO2-HA (doped with Zn2+) composites were successfully synthesized by the sol-gel method. After alkali heat treatment, the cracks in the HA coating of Ti6Al4V were reduced, and its surface wettability and corrosion resistance were improved. The addition of TiO2 and Zn2+ increases the integrity of the HA coating, improving the corrosion resistance and wettability. Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) reached 69.3% and 96.9%, respectively, indicating an improvement in antibacterial properties. |
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