| 李丽丽,马凤仓,何代华.掺Mg2+的ZIF-8材料的制备及抗菌和促成骨性能研究[J].有色金属材料与工程,2024,45(5):33-40. |
| 掺Mg2+的ZIF-8材料的制备及抗菌和促成骨性能研究 |
| Preparation of ZIF-8 materials doped with Mg2+ and study on its antibacterial and bone properties |
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| DOI：10.13258/j.cnki.nmme.20230215001 |
| 中文关键词: Mg2+ ZIF-8 金属有机框架 抗菌 成骨 |
| 英文关键词:Mg2+ ZIF-8 metal-organic framework antibacterial osteogenesis |
| 基金项目:国家自然科学基金资助项目(51201107)；上海市自然科学基金资助项目(17ZR1419600) |
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| 中文摘要: |
| 金属有机框架材料被广泛应用于种植体、骨修复等医疗领域。选用二甲基咪唑为有机配体，Mg2+、Zn1+为金属结节，通过溶剂热法在室温下成功合成纳米级Mg@ZIF-8有机框架材料。Mg@ZIF-8纳米颗粒为正十二面体结构，粒径为200～400 nm，具有Mg–N、Zn–N、C–N、C=C、C=N、C-H官能团，在酸性微环境下不稳定，以上物理表征与ZIF-8相似。抗菌实验结果表明：随着Mg2+浓度的升高，Mg@ZIF-8对大肠杆菌的抗菌性能逐步提高，而且一定浓度的Mg2+对金黄色葡萄球菌的抗菌性能也有所提高。体外矿化实验表明：Mg2+能够促进钛片表面P、Ca的沉积。Mg@ZIF-8有机框架材料在植入物领域有良好的应用前景。 |
| 英文摘要: |
| Metal-organic framework materials are widely used in implants, bone repair and other medical fields. In this study, dimethylimidazole was selected as the organic ligand and magnesium ion and zinc ion were used as metal nodules, and nanoscale Mg@ZIF-8 organic framework materials were successfully synthesized by solvothermal method under room temperature conditions. The nanoparticles have a regular dodecahedral structure, a size of 200-400 nm, Mg–N, Zn–N, C–N, C=C, C=N and C-H functional groups, and are unstable in an acidic microenvironment, and the above physical characteristics are similar to ZIF-8. The results of antibacterial experiments and in vitro mineralization experiments were also carried out, and the results of antibacterial experiments showed that with the increase of magnesium ion addition concentration, its antibacterial performance against Escherichia coli gradually improved, and the antibacterial performance of a certain concentration of Mg2+ against Staphylococcus aureus was also improved. In vitro mineralization experiments showed that the addition of magnesium ions could promote the deposition of phosphorus and calcium on the surface of titanium sheets. Mg@ZIF-8 organic framework materials have good application prospects in the field of implants. |
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