| 吕恺洪,马凤仓,何代华,刘平,赖红昌,史俊宇,宋琳.壳聚糖包覆ZIF-90的药物释放及抗菌性能研究[J].有色金属材料与工程,2024,45(1):34-39. |
| 壳聚糖包覆ZIF-90的药物释放及抗菌性能研究 |
| Study on drug release and antibacterial properties of Chitosan Coated ZIF-90 |
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| DOI：10.13258/j.cnki.nmme.20220216002 |
| 中文关键词: ZIF-90 壳聚糖 左氧氟沙星 药物释放 抗菌 |
| 英文关键词:ZIF-90 chitosan levofloxacin antibacterial drug release |
| 基金项目:国家自然科学基金资助项目（51771119）；上海市自然科学基金资助项目（17ZR1419600）；上海市高性能医疗器械材料工程中心资质项目（20DZ2255500） |
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| 中文摘要: |
| 以沸石咪唑骨架(zeolite imidazole framework, ZIF)为载体，高效合成了新型生物相容性抗菌药物缓释系统Levo@ZIF-90@CS。将抗菌药物左氧氟沙星(levofloxacin, Levo)负载到ZIF-90分子筛中，载药量为481 mg/g。在药物释放过程中，壳聚糖(chitosan, CS)作为一种pH敏感的生物材料，通过席夫碱反应共价修饰在ZIF-90表面，提高了复合材料的pH响应性。在pH=5.5的酸性条件下(细菌通过代谢导致局部酸性微环境)快速释放Levo，92%的Levo在40 h内被释放，而在正常环境下40 h的释放量为46%。抗菌试验结果表明，Levo@ZIF-90@CS对大肠杆菌、金黄色葡萄球菌均有较好的抑制作用。Levo@ZIF-90@CS具有较高的载药量和较好的抗菌性能，可作为一种良好的抗菌药物释放系统。 |
| 英文摘要: |
| Using zeolite imidazole framework (ZIF) as a carrier, a new biocompatible antibacterial drug sustained-release system Levo@ZIF-90@CS was efficiently synthesized. The antibacterial drug levofloxacin (Levo) was loaded into ZIF-90 molecular sieve, and the drug loading was about 481 mg/g. During the drug release process, chitosan (CS), as a pH-sensitive biological material, is covalently modified on the surface of ZIF-90 through aldoamine condensation to improve the pH responsiveness of the composite Levo@ZIF-90@CS. By releasing a large amount of Levo under acidic conditions pH = 5.5 (bacterial metabolism leads to a local acidic microenvironment), about 92% of Levo was released within 40 h, while the amount released under normal conditions, about 46% of Levo was released within 40 h. The results of antibacterial experiments show that Levo@ZIF-90@CS has inhibitory effects on E. coli and Staphylococcus aureus. According to the corresponding experimental results, Levo@ZIF-90@CS has high Levo drug loading, great antibacterial performance, and can be used as a good antibacterial drug release system. |
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