| 巨鹏亮,奚正星,赵金木,朱永都,马凤仓.镁掺杂微弧氧化TiO2多孔涂层的制备及其生物学性能研究[J].有色金属材料与工程,2026,47(3):39-48. |
| 镁掺杂微弧氧化TiO2多孔涂层的制备及其生物学性能研究 |
| Preparation and biological properties of Mg-doped porous TiO2 coatings by micro-arc oxidation |
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| DOI：10.13258/j.cnki.nmme.20260413001 |
| 中文关键词: 微弧氧化 镁掺杂 抗菌性能 生物相容性 心血管植入器械 |
| 英文关键词:micro-arc oxidation Magnesium doping antibacterial property biocompatibility cardiovascular implants |
| 基金项目:国家自然科学基金资助项目(51771119)；上海市自然科学基金资助项目(17ZR1419600) |
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| 中文摘要: |
| 针对心脏起搏器固定钩界面整合差与易感染的临床痛点，本文采用微弧氧化技术在纯钛表面制备了镁掺杂的多孔TiO2涂层。结果表明，适量镁掺杂未改变锐钛矿相，但显著均化了多孔拓扑形貌，亲水性大幅提升（接触角低至31.2°）。改性涂层展现出强效广谱抑菌活性（抑菌率超90%）。其中，TiO2-Mg2组综合性能最优：溶血率仅1.30%，自由基清除率达86.2%，细胞存活率达95.5%且显著促进心肌细胞铺展。该涂层通过物理-化学协同调控，兼顾了促组织整合、抗凝血与抗氧化功能，为心血管植入器械表面功能化提供了坚实参考。 |
| 英文摘要: |
| To address the clinical challenges of poor interfacial integration and high infection risk associated with pacemaker fixation hooks, magnesium-doped porous TiO2 coatings were prepared on pure titanium surfaces via micro-arc oxidation. The results indicate that appropriate magnesium doping did not alter the anatase phase but significantly homogenized the porous topological morphology, leading to a substantial improvement in hydrophilicity (with the contact angle reduced to 31.2°). The modified coatings exhibite potent broad-spectrum antibacterial activity (inhibition rate >90%). Notably, the TiO2-Mg2 group demonstrate the optimal comprehensive performance: a hemolysis rate of only 1.30%, a free radical scavenging rate of 86.2%, and a cell viability of 95.5%, while significantly promoting the spreading of cardiomyocytes. Through synergistic physical-chemical regulation, this coating achieves a combination of enhanced tissue integration, favorable hemocompatibility, and antioxidation functions, providing a solid reference for the surface functionalization of cardiovascular implant devices. |
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