| 涂洁,欧阳瑞镯.多功能纳米材料在声动力治疗领域的研究进展[J].有色金属材料与工程,2026,47(3):28-38. |
| 多功能纳米材料在声动力治疗领域的研究进展 |
| Recent advances in multifunctional nanomaterials for sonodynamic therapy |
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| DOI：10.13258/j.cnki.nmme.20260330001 |
| 中文关键词: 声动力治疗 肿瘤微环境 靶向运输 声敏性能 多功能纳米材料 |
| 英文关键词:sonodynamic therapy tumor microenvironment targeted delivery sonosensitization performance multifunctional nanomaterials |
| 基金项目:中国五矿集团有限公司科技专项计划项目（2022ZXA02） |
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| 中文摘要: |
| 声动力治疗（sonodynamic therapy, SDT）是一种运用低强度超声刺激声敏化剂产生声化学和声力学效应杀死肿瘤细胞或细菌的新兴无创的治疗方法。SDT由于具有穿透能力强、精准度高、毒副作用小、无组织创伤和可诱导免疫原性细胞死亡等优势，与光动力治疗相比，更适用于深部组织治疗，在生物医学领域具有广阔的应用前景。然而，SDT受到复杂的肿瘤微环境、药物运输无特异性靶向和声敏性能差等条件的限制，造成治疗效果低下。因此，为了解决这些问题，设计和修饰声敏剂以改善其功能特性对于开发提高SDT效率的策略至关重要。本文综述了目前公认的SDT机制和基于多功能纳米材料从调节肿瘤微环境、优化靶向运输、改善声敏性能3个角度提高SDT疗效的各种策略。此外，还讨论了SDT在目前发展中面临的挑战和局限性。 |
| 英文摘要: |
| Sonodynamic therapy (SDT) is an emerging non-invasive treatment modality that uses low-intensity ultrasound to activate sonosensitizers, generating sonochemical and sonomechanical effects for the eradication of tumor cells or bacteria. Owing to its advantages, including deep tissue penetration, high precision, low toxicity, minimal tissue damage, and the ability to induce immunogenic cell death, SDT is more suitable for treating deep-seated tissues than photodynamic therapy and holds broad application prospects in the biomedical field. However, the therapeutic efficacy of SDT is often constrained by the complex tumor microenvironment, lack of specific targeting in drug delivery, and suboptimal sonosensitization performance. Therefore, addressing these challenges through the design and functional modification of sonosensitizers is critical for developing strategies to enhance SDT efficiency. This review summarizes the currently recognized mechanisms of SDT and provided an overview of various strategies based on multifunctional nanomaterials to improve SDT efficacy from three perspectives: modulating the TME, optimizing targeted delivery, and enhancing sonosensitization performance. In addition, the challenges and limitations in the current development of SDT are discussed. |
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