| 徐勉,何斌.气管插管表面天然植酸复合抗菌抗痰栓涂层的制备与性能[J].有色金属材料与工程,2026,47(3):49-58. |
| 气管插管表面天然植酸复合抗菌抗痰栓涂层的制备与性能 |
| Preparation and properties of natural phytic acid-based composite coating with antibacterial and anti-sputum properties on endotracheal tubes |
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| DOI：10.13258/j.cnki.nmme.20260228001 |
| 中文关键词: 气管插管 植酸 抗菌 抗痰栓 |
| 英文关键词:endotracheal tube phytic acid antibacterial anti-sputum plug |
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| 中文摘要: |
| 气管插管长期插管会导致痰液完全闭塞管路，还会增加生物膜相关感染，例如呼吸机相关性肺炎。针对该问题，本研究使用植酸（phytic acid，PA）和聚六亚甲基双胍盐酸盐（polyhexamethylene biguanide hydrochloride，PHMB）在气管插管表面构建PA-PHMB复合涂层，以实现抗菌和抗痰栓的双重效果。相比原始导管，该涂层显著提高了气管插管表面的抗菌性和亲水性。涂层对于铜绿假单胞菌及金黄色葡萄球菌的杀灭率分别达到91.8%和99.4%，蛋白质粘附降低61.4%，痰栓形成减少59.5%，表明该复合涂层具有优异的抗菌性能和防污性能。本研究开发的PA-PHMB复合涂层在减少气管插管相关感染和维持患者气道通畅方面具有潜在应用价值。 |
| 英文摘要: |
| Prolonged endotracheal intubation can lead to complete occlusion of the tube lumen by sputum plugs and increases the risk of biofilm-associated infections, such as ventilator-associated pneumonia. To address these issues, this study constructed a PA-PHMB composite coating on the surface of endotracheal tubes using phytic acid (PA) and polyhexamethylene biguanide hydrochloride (PHMB), aiming to achieve both antibacterial and anti-sputum-plug effects. Compared with the unmodified catheter, the coating significantly improved the antibacterial properties and hydrophilicity of the endotracheal tube surface. The coating achieved bacterial eradication rates of 91.8% against Pseudomonas aeruginosa and 99.4% against Staphylococcus aureus, reduced protein adhesion by 61.4%, and decreased sputum plug formation by 59.5%, demonstrating excellent antibacterial and antifouling performance. The PA-PHMB composite coating developed in this study holds potential value for reducing endotracheal tube-associated infections and maintaining patient airway patency. |
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