| 刘学雨,张豫龙,缪煜清,欧阳瑞镯.无机金属声敏剂在肿瘤声动力治疗中的应用现状[J].有色金属材料与工程,2025,46(1):11-20. |
| 无机金属声敏剂在肿瘤声动力治疗中的应用现状 |
| Applications status of inorganic metal sonosensitizers in sonodynamic therapy of tumors |
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| DOI：10.13258/j.cnki.nmme.20241224002 |
| 中文关键词: 声动力治疗 无机金属声敏剂 超声 活性氧 |
| 英文关键词:sonodynamic therapy inorganic metal sonosensitizers ultrasound reactive oxygen species |
| 基金项目:中国五矿集团有限公司科技专项计划资助项目（2022ZXA02） |
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| 中文摘要: |
| 随着纳米医学技术的蓬勃发展，声动力治疗（sonodynamic therapy，SDT）作为一种新兴的非侵入性治疗方法，凭借其能对肿瘤深部进行治疗且对周围组织损伤小的特点，逐渐成为研究的热点。声敏剂是SDT中不可或缺的组成部分，因其结构和性质直接决定SDT的效果。与传统有机声敏剂相比，无机金属声敏剂具有稳定性高、形态可控且在人体内循环时间长的优势，这极大地扩展了其在SDT中的研究应用。对SDT的可能机制，即空化效应和活性氧的产生进行了简要探讨；概述了无机金属声敏剂的配方设计、抗肿瘤作用机制及SDT的优化策略；讨论了SDT当前面临的挑战和未来的发展方向。以期为今后无机金属声敏剂在SDT中的筛选提供参考。 |
| 英文摘要: |
| With the rapid development of nanomedicine technology, sonodynamic therapy (SDT), as an emerging non-invasive therapy method, has gradually become a research hotspot due to its ablility to effectively treat deep tumors while causing minimal damage to surrounding tissues. Sonosensitizer is an indispensable component in the SDT, as their structure and properties directly determine the efficacy of SDT. Compared with the traditional organic sonosensitizers, inorganic metal sonosensitizers offer advantages such as higher stability, controllable morphology and long circulation time in the human body, which greatly extend their research applications in SDT. The possible mechanisms of SDT were briefly investigated, i.e., cavitation effect and generation of reactive oxygen species. The formulation designs, anti-tumor mechanisms and optimization strategies for treating tumors of inorganic metal sonosensitizers were summarized, and the current challenges and future development directions of SDT were discussed. It is expected to provide a reference for the future screening of inorganic metal sonosensitizers in SDT. |
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