| 马凤仓,陈赛,耿芳,刘新宽,李伟.β-TCP/PLLA复合材料的制备与降解性能[J].有色金属材料与工程,2016,37(5):197-201. |
| β-TCP/PLLA复合材料的制备与降解性能 |
| Preparation and Degradation Property of β-TCP/PLLA Composites |
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| DOI：10.13258/j.cnki.nmme.2016.05.002 |
| 中文关键词: 聚左旋乳酸 复合材料 力学性能 降解性能 |
| 英文关键词:poly-L-lactic acid composites mechanical property degradation property |
| 基金项目:国家自然科学基金项目（51471110）；上海市自然科学基金项目（09ZR1422100） |
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| 中文摘要: |
| 采用溶液共混法制备不同β-磷酸三钙（β-tricalcium phasphate，β-TCP）质量分数的复合材料，并将纯聚左旋乳酸（PLLA）和复合材料置于模拟体液中降解3个月，用万能材料试验机测试纯PLLA和复合材料的弯曲强度、拉伸强度和弯曲模量，用扫描电子显微镜（SEM）观察其断面形貌.结果表明：少量β-TCP的加入可以使复合材料弯曲强度和拉伸强度增大，随着β-TCP的进一步加入，复合材料的弯曲强度和拉伸强度均减小，而复合材料的弯曲模量随着β-TCP的加入逐渐增大；降解后不同β-TCP含量的复合材料的弯曲强度均有所降低，但降幅不同，所有复合材料在前6周弯曲强度衰减较快，第6~12周强度衰减趋缓；纯PLLA体外降解时，弯曲强度衰减明显快于β-TCP/PLLA复合材料；第12周时复合材料的弯曲强度仍有17.8~32.4 MPa，高于松质骨的（11.5±2.1）MPa，满足松质骨骨折内固定器的要求. |
| 英文摘要: |
| PLLA composites with various β-tricalcium phasphate(β-TCP) mass fractions were prepared by solution blended method.Pure PLLA and various composites degraded in the simulated body fluids for 3 months.Then,bending strength,tensile strength and bending modulus of the PLLA and composites were tested by universal material testing machine.Fracture of the composites was observed by SEM.The results indicate that small amount of β-TCP can increases bending strength and tensile strength of the composites.As the increase in β-TCP addition in the composites,the bending strength and tensile strength of the composite decrease,but the bending modulus of composites increases.The bending strength of the composites with different β-TCP mass fractions decreases after degradation,but the decreasing rate of the bending strength is varying with time.The bending strength of all composites decreases rapidly in the first six weeks,and the decreasing rate slows down in next six to twelve weeks,decreasing rate of bending strength of PLLA is larger than that of β-TCP/PLLA composites.Bending strength of composites is 17.8-32.4 MPa after twelve weeks degradation,and it is higher than cancellous bone whose bending strength is(11.5±2.1)MPa.The composites meet the strength requirement of the fixation for cancellous bone. |
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