| 柴宇臻,马凤仓,宋文煊.基于引入疏水官能团调节MOF涂层的水稳定性和抗菌性能研究[J].有色金属材料与工程,2025,46(4):41-48. |
| 基于引入疏水官能团调节MOF涂层的水稳定性和抗菌性能研究 |
| Study on the water stability and antibacterial properties of MOF coatings regulated by introducing hydrophobic functional groups |
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| DOI：10.13258/j.cnki.nmme.20240315001 |
| 中文关键词: TA4 MOF涂层 电沉积处理 雷洛昔芬 水稳定性 |
| 英文关键词:pure titanium MOF coating electrodeposition treatment raloxifene water stability |
| 基金项目:国家自然科学基金资助项目（51771119）；上海市自然科学基金资助项目（17ZR1419600） |
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| 中文摘要: |
| 在生物医学领域中，金属有机骨架（metal-organic frameworks, MOF）因其卓越的可设计性和功能性而备受瞩目。然而，MOF在水介质中的稳定性欠佳，在酸性环境易于降解，这成为制约其临床实用的难题。本研究运用电沉积与浸涂技术，通过引入疏水性官能团优化MOF稳定性。在纯钛上构筑了一种由层状双氢氧化物（layered double hydroxides, LDH）和表层沸石咪唑骨架（ZIF-8）组成的双层涂层。LDH既扮演着防护角色，又能强化底层与表层ZIF-8间的界面结合强度。ZIF-8如同一层铠甲，有效阻挡腐蚀离子透过微孔缺陷侵入。此外，研究利用了锌基MOF与盐酸雷洛昔芬（raloxifene hydrochloride tablets, RHT）间的协同效应，在纯钛表面构建出兼具药物负载与稳定增强功能的多功能涂层。实验表面，该涂层能够实现Zn2+离子和RHT分子达14 d以上的持续释放。MOF与RHT的有效整合，提升了MOF在水环境中的稳定性。 |
| 英文摘要: |
| In the biomedical field, metal-organic frameworks (MOF) have attracted much attention due to their excellent design-ability and functionality. However, the stability of MOF in water medium is poor, and it is easy to degrade in acidic environment, which has become a difficult problem restricting its clinical application.In this study, electrodeposition and dip coating techniques were used to optimize the stability of MOF by introducing hydrophobic functional groups. On the titanium alloy to construct a kind of layered double hydroxide (LDH) and the surface of zeolite imidazole skeleton-8 (ZIF-8) consisting of double coating. LDH not only plays a protective role, but also strengthens the interface bonding strength between the bottom layer and the surface layer ZIF-8. ZIF-8 acts like a layer of armor, effectively blocking the invasion of corrosive ions through microporous defects.the use of zinc base MOF and raloxifene hydrochloride (RHT), the synergistic effect between the pure titanium surface construct both drug load and stability enhancement of multi-functional coating. The experiment shows that the coating was able to achieve continuous release of Zn2+ ions and RHT molecules for more than 14 days. The effective integration of MOF and RHT improves the stability of MOF in water environment. |
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