期刊信息
  • 主管单位:
  • 上海市科学技术协会
  • 主办单位:
  • 上海有色金属学会
    上海理工大学
  • 名誉主编:
  • 陈兴章
  • 主    编:
  • 刘 平
  • 地    址:
  • 上海市军工路516号
  • 邮政编码:
  • 200093
  • 联系电话:
  • (86)021-55781550
  • 电子邮件:
  • nmme@usst.edu.cn
  • 国际标准刊号:
  • 2096-2983
  • 国内统一刊号:
  • 31-2125/TF
  • 单    价:
  • 8.00
  • 定    价:
  • 60.00
朱彦西,陈爱英,毛燕飞.抗生素亚胺培南探针分子设计及传感性能研究[J].有色金属材料与工程,2024,45(2):55-61.
抗生素亚胺培南探针分子设计及传感性能研究
Design and sensing property of probe molecular for imipenem antibiotic
  
DOI:10.13258/j.cnki.nmme.20230320001
中文关键词:  石墨烯量子点  掺杂  抗生素  荧光性能  传感特性
英文关键词:graphene quantum dots  doping  antibiotics  fluorescence performance  sensing property
基金项目:国家自然科学基金资助项目(5177121)
作者单位E-mail
朱彦西 上海理工大学 材料与化学学院, 上海 200093  
陈爱英 上海理工大学 材料与化学学院, 上海 200093 aychen@usst.edu.cn 
毛燕飞 上海交通大学医学院附属新华医院 麻醉与重症医学科, 上海 200092 maoyanfei@xinhuamed.com.cn 
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中文摘要:
      抗生素亚胺培南(imipenem,IPM)用药治疗败血症患者感染需要快速做出反应,目前的血药监测方法严重延迟药物注射。设计金属元素掺杂型石墨烯量子点(graphene quantum dots,GQDs),可实现荧光法快速测定IPM和开辟荧光法检测抗生素的新途径。采用水热法制备了铁掺杂GQDs (Fe-GQDs),用于快速探测IPM。采用透射电子显微镜(transmission electron microscopy,TEM)、X射线光电子能谱(X-ray photoelectron spectroscopy,XPS)以及荧光光谱等方法,探讨不同铁源起始剂对GQDs荧光性能及传感性能的影响,并分析了乙酸铁为铁源制备的Fe-GQDs的微观结构及荧光性能。结果表明:以乙酸铁为起始剂制备的Fe-GQDs荧光性能最佳,且对IPM具有显著的荧光淬灭效应。所制备的Fe-GQDs荧光淬灭强度(F/F0)与IPM浓度(concentration,C)呈线性关系,线性方程为${F/}{{F}}_{\text{0}}\text{= 0.983}-\text{4.23×}{\text{10}}^{-3}\text{}$C,线性相关系数(R2)为 0.997,线性范围为0.007~0.073 g/L。Fe-GQDs探针分子对血浆中常见有机分子和金属离子具有良好的抗干扰性,检测IPM误差为1.6%~4.6%。
英文摘要:
      Medication management of antibiotic imipenem (IPM) in the treatment of sepsis infection requires rapid response, however, the current monitoring methods of blood drugs severely delay drug injection. The aim of this work is to design metal element doped graphene quantum dots (GQDs), which can rapidly detect IPM by fluorescence method, opening up a new way for fluorescence detection of antibiotics. Iron doped GQDs (Fe-GQDs) were prepared by hydrothermal method for rapid detection of IPM. The effects of different precursors of iron sources on the fluorescence and sensing performance of GQDs were investigated using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), fluorescence spectroscopy, etc. The microstructure and fluorescence properties of Fe-GQDs prepared with iron acetate were analyzed. The results showed that Fe-GQDs prepared with iron acetate as the precursor exhibited the best fluorescence performance and a significant fluorescence quenching effect on IPM. The fluorescence quenching intensity (F/F0) of the as-prepared Fe -GQDs was linearly related to the concentration (C) of IPM, where the linear equation was $ {F/}{{F}}_{\text{0}}\text{}\text{=}\text{}\text{0.983}-\text{4.23}\text{}\text{×}{\text{}\text{10}}^{-3}{C} $ with a linear correlation coefficient (R2) of 0.997 and a linear range of 0.007-0.073 g/L. The Fe-GQDs probe molecules delivered a good anti-interference performance against common organic molecules and metal ions in plasma with a detection error of 1.6%-4.6% for sensing IPM.
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